Young‐Hwan Jo

This study shows that optogenetic activation of liver-innervating vagal sensory neurons increases anxiety-like behavior in mice by activating the NTS-LC circuit.

This study investigates how Magel2 gene deletion in hypothalamic POMC neurons affects stress-induced anxiety and spatial learning in male mice, revealing sex-specific behavioral impacts.

This study shows that liver-innervating vagal sensory neurons contribute to hepatic steatosis and anxiety-like behavior in mice on a high-fat diet, and their removal prevents obesity and improves metabolic outcomes.

This study shows that parasympathetic cholinergic neurons innervating the liver prevent hepatic steatosis in mice on a high-fat diet by promoting browning of white adipose tissue and altering bile acid metabolism.

The paper identifies sex-specific transcriptional differences in vagal sensory neurons of mice, linking them to metabolic homeostasis and potential sex-specific treatments for metabolic disorders.