Jie Chen

This study identifies drug targets and resistance mechanisms in microsporidia using forward genetics in C. elegans.

The paper tests 15 yeast-targeted inhibitors against the microsporidian Nematocida parisii and finds that most are ineffective, except tunicamycin.

This study screens 4,080 compounds to identify inhibitors of microsporidia spores, finding 17 effective compounds that prevent infection in C. elegans.

This study identifies distinct CD8 T cell subsets during chronic Toxoplasma gondii infection, showing a unique differentiation pathway that differs from viral and cancer models.

The paper screens compounds in C. elegans to identify benzenesulfonamides that inhibit microsporidia spores, showing effectiveness against multiple species.

This paper identifies NbSPN14, a serine protease inhibitor secreted by Nosema bombycis, which inhibits host cell apoptosis by interacting with BmICE, providing insights into pathogen-host interactions.

This paper introduces a high-efficiency gene editing method for Anopheles sinensis using ReMOT control, achieving high editing efficiency through adult mosquito injection.

This study shows that crayfish (Procambarus clarkii) can harbor and transmit the microsporidian parasite Enterocytozoon hepatopenaei, posing a risk to shrimp farming.

The paper screens the Pandemic Response Box to identify anti-microsporidia compounds using C. elegans infected with Nematocida parisii, finding four effective inhibitors.