Author

Brittany M. Bowman

University of North Carolina at Chapel HillORCID 0000-0003-2054-6169Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Michael B. MajoriD· 2 shared Abid Ali KhaniD· 1 shared Amanda L. Brademeyer· 1 shared Brian D. StrahliD· 1 shared Cheng ZhangiD· 1 shared Chorlada PaiboonrungruangiD· 1 shared Christine A. MillsiD· 1 shared Emily WilkersoniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

Michael B. MajorORCID

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2 papers

Recent·Most cited

Cell BiologyNature Cell BiologyPeer-reviewedAug 1, 2025

SETD2 maintains nuclear lamina stability to safeguard the genome

Abid Ali Khan, Cheng Zhang, Phu G. Nguyen…·Brian D. Strahl

This study identifies a non-catalytic function of SETD2 in maintaining nuclear lamina stability and genome integrity through its N-terminus interactions.

21 citations

humanChIP-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintFeb 13, 2025

Pyrimethamine and a potent analogue WCDD115 inhibit NRF2 by suppressing DHFR and one-carbon metabolism

Julius Chembo, Brittany M. Bowman, Kyle M. LaPak…·Michael B. Major

This paper identifies Pyrimethamine and its derivative WCDD115 as potent inhibitors of NRF2 by targeting DHFR and one-carbon metabolism, with WCDD115 showing 22-fold greater efficacy.

4 citations

humanmetabolomics

𝕏 PostBluesky