Christine A. Mills

This study identifies APOE interacting with COX-2 on lipid droplets, showing APOE3 promotes and APOE4 suppresses COX-2 activity and prostaglandin production.

This study identifies RNF25's role in protecting DNA replication forks from degradation, independent of its ubiquitin signaling functions.

This study identifies a non-catalytic function of SETD2 in maintaining nuclear lamina stability and genome integrity through its N-terminus interactions.

This study examines the effects of sleep deprivation on synaptic vulnerability across developmental stages in mice, finding heightened sensitivity in juveniles and links to ASD risk.

This paper identifies and characterizes RA-0002034, a covalent inhibitor of CHIKV nsP2 protease, showing potent inhibition and selectivity against alphaviruses.

The paper identifies SMN complex binding partners and reveals conserved connections to chaperone systems, linking chaperone dysfunction to ALS and SMA.

This paper shows APC/C activity is essential to maintain CDK4/6 inhibitor-induced arrest by preventing premature S phase entry through degradation of cyclin A.

The paper uses proteomics and PLK1 inhibition to identify proteins degraded at G2/M, showing PLK1's role in coordinating proteolysis via SCF ligases and linking AKAP2 to cell cycle control.

The paper shows a monoclonal antibody against EZH2 cross-reacts with SAFB, highlighting the need for orthogonal assays in studying RNA-chromatin interactions.

This study identifies SAFB-associated RNAs in mouse embryonic stem cells and shows SAFB promotes gene expression by binding purine-rich regions in nascent transcripts.