Victoria L. Bautch

The paper uses single-nucleus RNA sequencing to analyze intestinal tissues from NEC patients and controls, identifying disease-specific gene expression programs across multiple cell types.

ELDR-Glo is a fluorescent biosensor that estimates relative cell age and quiescence depth, functioning in both live and fixed cells.

This study shows that SUN2 in the nucleus regulates endothelial cell-matrix interactions, affecting vascular homeostasis and barrier function through microtubule and matrix metalloprotease mechanisms.

The paper develops a mechanistic model of sFLT1 secretion dynamics, showing that a delay differential equation system best fits experimental data and identifies key constrained parameters.

The paper quantifies how VEGF ligand binding affects trafficking of VEGFR1, VEGFR2, and NRP1 in human endothelial cells, showing that VEGFR2 internalization is ligand-dependent while VEGFR1 is not.

The paper identifies biological principles governing postnatal aortic growth, showing it scales with the vertebral column and relies on differentiated cell proliferation rather than stem cells.

The paper introduces a novel PIP-FUCCI reporter to study endothelial cell cycle stages in postnatal retinal vessels and identifies G2 stalling in tip cells.

The paper quantifies trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in HUVECs, showing differences in trafficking rates and surface localization compared to non-human endothelial cells.

This study shows SMAD6 in endothelial cells balances ALK1 signaling to regulate vascular development and junction integrity, preventing hemorrhage and vascular defects in the embryonic liver.