Michael Lazarou

The paper introduces AIVE, an AI-assisted method for segmenting membrane boundaries in vEM data, revealing a new type of mitochondrial contact called intrusions.

This paper introduces a pH-sensitive fluorescent probe, CalRexin:pHrodo Red, for detecting autophagy through high throughput imaging and validates its utility in screening autophagy modulators.

This study maps the structural pathway of class III PI 3-kinase activation by showing how N-myristoylation of VPS15 stabilizes the inactive conformation and how GTP binding promotes activation.

This study compares mitochondrial remodelling in humans after moderate-intensity continuous exercise and sprint-interval exercise, showing divergent adaptations in mitochondrial structure, function, and protein expression.

The paper identifies presynapses as sites of mitophagy in neurons and shows their role in preventing axon degeneration when mitophagy is defective.

This study identifies PPTC7 as a cofactor for SCFFBXL4-mediated degradation of BNIP3 and NIX, suppressing mitophagy and revealing a feedback mechanism to regulate mitochondrial homeostasis.

This study identifies NAP1 and SINTBAD as regulators of mitophagy, inhibiting OPTN-driven initiation while promoting NDP52-driven progression.

This study identifies a RAB7A phosphoswitch regulated by TBK1 that modulates Rubicon and Pacer interactions to control PINK1/Parkin-dependent mitophagy.

The paper investigates PINK1's interaction with nucleotides and kinetin, revealing structural changes and binding constraints that affect its activity and mitophagy.

This study identifies that Helicobacter pylori VacA is processed in endosomes by proteases into active forms that mediate intracellular effects, revealing a novel mechanism of toxin activation.

This study compares exercise-induced changes in autophagy markers in human and rodent skeletal muscle, finding differences in LC3B-II protein levels and autophagy flux responses.