Annan SI Cook

This study identifies a stepwise pathway for ULK1 recruitment to membranes during autophagy, involving WIPI proteins and a PVP motif in ULK1.

This study identifies structural mechanisms of gp130 mutant activation in IHCAs using cryo-EM and mutagenesis, revealing two distinct dimer conformations and their activation dependencies.

This study maps the structural pathway of class III PI 3-kinase activation by showing how N-myristoylation of VPS15 stabilizes the inactive conformation and how GTP binding promotes activation.