Sascha Martens

This study identifies a stepwise pathway for ULK1 recruitment to membranes during autophagy, involving WIPI proteins and a PVP motif in ULK1.

The paper identifies a lipid transfer-dependent feedback loop that activates ATG9A compartments during autophagy initiation by enhancing ATG2A-mediated lipid transfer and ATG8 lipidation.

This study identifies Atg1-mediated phosphorylation of Atg2 as a mechanism to activate lipid transfer during autophagosome biogenesis.

This study shows that TAX1BP1 recruitment to Tau aggregates reactivates autophagy through ULK1 and TBK1, enabling their clearance in neurodegenerative diseases.

This study identifies the mechanism of ATG2A-mediated lipid transport in autophagy, revealing N-terminal helices as gates that regulate lipid transfer efficiency.

The paper investigates how TAX1BP1 recruits the autophagy machinery to switch from cargo collection to sequestration in aggrephagy.

This study identifies NAP1 and SINTBAD as regulators of mitophagy, inhibiting OPTN-driven initiation while promoting NDP52-driven progression.

The paper shows Faa1 binds membranes to activate fatty acids, promoting autophagosome biogenesis through a positive feedback loop.