Harris H. Wang

This study shows that evolving the Drosophila gut microbiome to resist oxidative stress improves host health and extends lifespan.

MCSPACE infers microbiome spatiotemporal dynamics from co-localization data, showing superior performance over existing methods in mice and human datasets.

This study shows colibactin-producing E. coli promote GEAC carcinogenesis by increasing proliferation, DNA damage, and cancer pathways, while also inducing autophagy and differentiation.

SAMPL-seq identifies spatial hubs in the human gut microbiome by sampling micron-scale sub-communities and analyzing microbial co-occurrence across individuals and time.

This study shows that high-fat diets promote GEAC by altering the microbiota-Bile Acid axis and inhibiting FXR, with FXR agonists like OCA slowing disease progression.

GENTANGLE is a computational tool for designing overlapping gene pairs in microbial genomes, enabling safer genetic engineering through gene entanglements.

This study compares the antibody evasion, ACE2 binding, and infectivity of SARS-CoV-2 BA.2.87.1 with EG.5.1 and JN.1, finding BA.2.87.1 has lower immune evasion and reduced infectivity.

This paper evaluates the antigenicity and receptor affinity of the SARS-CoV-2 BA.2.86 subvariant, finding it not more resistant to human sera than other variants but with specific mAb resistance and high receptor affinity.

This paper demonstrates the successful restoration of valine biosynthesis in mammalian cells by integrating synthetic pathways from E. coli, showing that ancient metabolic pathways can be reactivated in metazoans.

This paper introduces an improved CRISPR-based system for high-efficiency, multiplexed bacterial genome engineering using RNA-guided integrases.

This paper identifies a novel CRISPR-Cas transcription activator, dCas9-AsiA, that can activate gene expression up to 200-fold in bacteria and is portable across species.

The paper describes a ribonuclease-based method for rRNA depletion in bacterial RNA-seq, validated on gut microbiota isolates and providing probe sets and an online tool for custom probe libraries.

This paper introduces a Cas-Transposon system for programmable DNA insertion, showing it increases transposition efficiency by over 300-fold at targeted sites.

The paper introduces DRAFTS, a method for multiplexed transcriptional measurement in cell-free systems, and shows functional differences in gene expression across bacterial species and hybrid lysates.

The paper introduces DIVERS, a method to quantify spatiotemporal dynamics and noise in microbiota abundances using replicate sampling and spike-in sequencing, applied to the human gut microbiome.

This study uses engineered CRISPR-Cas to capture real-time horizontal gene transfer events from gut microbiota at nucleotide resolution, revealing extensive and rapid transfer of plasmid types, particularly IncX.

The paper investigates how post-translational modifications in Escherichia coli regulate metabolic adaptation to environmental changes, showing their impact on fitness and pathway usage.