Zachary Madaj

This study shows that deleting Znrf3 in osteoblasts reduces trabecular bone mass and alters cortical bone structure, while Rnf43 deletion has minimal effects.

The paper investigates how G2019S LRRK2 interacts with metabolic syndrome in a mouse model of Parkinson's disease, showing systemic nucleotide and energy metabolism disruptions and mitochondrial dysfunction.

This study shows chronic high-fat diet-induced obesity does not increase cancer incidence in Trp53R270H/+ mice, despite significant obesity and long-term adiposity differences.

This study identifies FZD6 as a key driver of EMT and stromal remodeling in basal-like pancreatic cancer, downstream of SP1, with implications for therapeutic targeting.

This study identifies glucose-dependent glycosphingolipid biosynthesis as essential for CD8+ T cell expansion and tumor control, independent of energy production.

BifurcatoR identifies clinically relevant subgroups by analyzing variance patterns in biological data, revealing hidden structures in AML and obesity.

The paper shows that early life epigenetic variation can prime cancer-susceptibility states that persist into adulthood and correlate with poor prognosis in human cancers.

This study uses spatial transcriptomics to identify increased epithelium-macrophage signaling in endometriotic lesions, highlighting a new role for Complement 3 in lesion inflammation.

The paper shows that metabolite extracts contain active enzymes and demonstrates a new workflow to remove proteins for improved metabolomics.

This study develops a single-embryo metabolomics method to analyze metabolic and transcriptional changes in early Drosophila embryos with high temporal resolution.

This study integrates metabolomics and RNAseq from the same liver samples to show that prior metabolite extraction does not harm RNAseq quality and reveals pyrimidine metabolism as a key pathway in acute viral infection.

This paper performs a large meta-analysis of GWAS in dementia with Lewy bodies, identifying sex-specific genetic risk signals and highlighting the need for larger cohorts.

The paper finds increased levels of neurotoxic metabolites in mild COVID-19 patients, associated with inflammation and hypertension.

The paper shows that experimental colitis increases alpha-synuclein accumulation in the gut and brain, linking intestinal inflammation to Parkinson's disease pathology.

The paper tests if inhibiting the mitochondrial pyruvate carrier reduces synucleinopathy in PD models but finds no effect on Syn aggregation or neurodegeneration.

This study creates Lrp5-deficient rats using CRISPR/Cas9, showing reduced bone mass and abnormal retinal vasculature similar to human LRP5 deficiency.

This study shows that injecting α-synuclein fibrils into the olfactory bulb of mice reduces odor detection sensitivity, detected by plethysmography but not buried pellet tests.

This paper describes a new OCN-deficient mouse strain with no endocrine abnormalities, contrasting previous findings, and donates the strain for further study.

This study shows that loss of one Engrailed1 allele in mice increases α-synuclein aggregation after PFF injection, suggesting a role for En1 in PD pathology.