Bart O. Williams

This study shows that deleting Znrf3 in osteoblasts reduces trabecular bone mass and alters cortical bone structure, while Rnf43 deletion has minimal effects.

This study identifies FZD6 as a key driver of EMT and stromal remodeling in basal-like pancreatic cancer, downstream of SP1, with implications for therapeutic targeting.

The paper shows that ZNRF3/RNF43 ubiquitinates and degrades EGFR, and their loss increases EGFR signaling, promoting cancer growth.

This study shows that the Lgals3-R200S mutation in mice reduces galectin-3 secretion and alters bone mass differently in males and females.

This paper models a human FZD2 variant in mice, identifies limb and cleft palate phenotypes, and shows DKK1 inhibition can normalize limb defects.

This study creates a Lrp5 knockout rat model to study retinal vascular diseases, finding defects in retinal structure and function similar to human FEVR.

This study creates Lrp5-deficient rats using CRISPR/Cas9, showing reduced bone mass and abnormal retinal vasculature similar to human LRP5 deficiency.

This paper describes a new OCN-deficient mouse strain with no endocrine abnormalities, contrasting previous findings, and donates the strain for further study.