Li Li

The paper identifies Jade1 as a cofactor of Oct4 that selectively interacts with specific DNA configurations to enhance histone acetylation and transcriptional regulation.

This study shows NSD2 promotes cell durotaxis and drives the transition from PKD to TCRCC via integrin/FAK/AKT signaling, with implications for targeted therapies.

This study shows that H3K36me3, catalyzed by SETD2, maintains ISC stemness by regulating lipid metabolism and preventing senescence through chromatin remodeling and metabolic intervention.

The paper shows NSD2 maintains taurine biosynthesis via FMOs in intestinal epithelial cells, preventing barrier disruption in IBD.

This study shows NSD2 acts as a tumor suppressor in Kras-driven pancreatic cancer by regulating NF-kappa B signaling through multiple mechanisms.

This study shows that SETD2 deficiency in mice leads to increased oxidative stress and FasL-induced apoptosis in intestinal epithelial cells, contributing to IBD pathogenesis.

This study identifies a BRD4-GATA4 interaction that regulates mitochondrial homeostasis in adult cardiomyocytes by modulating gene expression related to energy production.