Robert W. Sprung

This study shows that daraxonrasib, a pan-RAS(on) inhibitor, effectively inhibits TNBC cell proliferation and tumor growth, either alone or in combination with a MEK inhibitor.

The paper develops a method to detect dynamic changes in enkephalin levels in mice during acute stress, revealing their release and correlation in the nucleus accumbens shell.

The paper introduces a synthetic toolkit for efficiently producing tyrosine phosphorylated proteins by leveraging signaling-inspired targeting interactions.

This study quantifies kinase protein abundance in human tissues using proteomic mass spectrometry, revealing heterogeneity in breast cancer subtypes and enabling clinical applications.

This study shows HTLV-1 infected T cells release small extracellular vesicles that promote bone loss by stimulating osteoclasts, independent of RANKL expression.

This study shows that MBI MYC mutations alter MYC localization and disrupt mRNA subcellular distribution and turnover, promoting leukemogenesis.