Galen H. Hostetter

This study shows chronic high-fat diet-induced obesity does not increase cancer incidence in Trp53R270H/+ mice, despite significant obesity and long-term adiposity differences.

This paper shows that a high-fat diet increases endometrial hyperplasia risk by reprogramming stromal fibroblasts to a pro-fibrotic state driven by estrogen.

This study identifies FZD6 as a key driver of EMT and stromal remodeling in basal-like pancreatic cancer, downstream of SP1, with implications for therapeutic targeting.

This paper presents an optimized workflow for high-throughput proteomic and phosphoproteomic analysis of FFPE tissues, achieving deep coverage and quantitative robustness comparable to TMT-based methods.

This study shows that LSD1 inhibition reduces lineage plasticity caused by BRAF and EGFR inhibitors in BRAFV600E colorectal cancer.

This study identifies PDAC cancer cell subpopulations using multiplexed glycan immunofluorescence and shows consistent aberrant glycan signatures in both tumor and blood samples, improving detection beyond CA19-9 alone.

The paper shows that early life epigenetic variation can prime cancer-susceptibility states that persist into adulthood and correlate with poor prognosis in human cancers.

This study identifies ZNFX1 as a master regulator of epigenetically-induced pathogen mimicry and inflammasome signaling in ovarian cancer, linking its expression to disease progression and survival.

The paper shows that ZNRF3/RNF43 ubiquitinates and degrades EGFR, and their loss increases EGFR signaling, promoting cancer growth.