Linda Faye van Dyk

This study shows high-dose MHV68 infection of macrophages causes inflammatory cell death independent of lytic replication, involving autophagy and pyroptosis.

This study shows that IFNγ and IL-4 regulate lytic infection in myeloid cells via JAK/STAT signaling, with IFNγ restricting lytic replication through multiple mechanisms.

This study evaluates the effects of CDK inhibitors on gammaherpesvirus reactivation, finding that broad-spectrum inhibitors reduce reactivation while targeted CDK4/6 inhibitors have nuanced effects depending on timing.

This study shows that myeloid cells infected by gammaherpesvirus 68 exhibit divergent outcomes regulated by viral and host factors, with IL-4 converting restricted infection to productive replication.