Author

Robert M. Brosh

National Institutes of HealthORCID 0000-0003-2676-4327Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Joshua A. SommersiD· 2 shared Alessandro NotoiD· 1 shared Annapaola FranchittoiD· 1 shared Anthony FernandeziD· 1 shared Benedetta Perdichizzi· 1 shared Binghui SheniD· 1 shared Carl L. Schildkraut· 1 shared Changxian SheniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Joshua A. SommersORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintApr 4, 2025

DNA2 and MSH2 activity collectively mediate chemically stabilized G4 for efficient telomere replication

Anthony Fernandez, Tingting Zhou, Robert Steven Esworthy…·Binghui Shen

The paper shows DNA2 and MSH2 work together to remove G4 structures at telomeres, preventing replication issues and telomere instability.

DOI 10.1101/2025.04.04.647332

humanDNA methylation

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Cell BiologyNature CommunicationsPeer-reviewedJan 27, 2025

PHOSPHORYLATION-DEPENDENT ASSOCIATION OF WRN WITH RPA IS REQUIRED FOR RECOVERY OF REPLICATION FORKS STALLED AT SECONDARY DNA STRUCTURES

Alessandro Noto, Pasquale Valenzisi, Flavia Di Feo…·Pietro Pichierri

This study shows that phosphorylation-dependent WRN-RPA interaction is essential for replication fork recovery after stalling at secondary DNA structures, preventing DNA damage and G4 accumulation.

19 citationstop 5%

humanexperimental assay

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