Jonghan Park

The paper develops a statistical mechanics approach to identify sequence features controlling DNA cyclizability, finding periodic features in highly cyclizable sequences and distinct patterns in low cyclizability.

This study shows that single nucleosomes encode A/B compartment information through biophysical properties, specifically condensability, which correlates with gene expression and is electrostatic in nature.

This paper develops a computational model to predict DNA mechanics from sequence, revealing mechanical selection in diverse eukaryotes and identifying extreme DNA mechanics in nature.