Author
Garvan Institute of Medical ResearchORCID 0000-0002-7313-3977Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Ariel Tennenhouse, Adva Mechaly, Tony Pham…·Sarel Jacob Fleishman
This paper introduces LAffAb, a method to co-optimize antibody affinity and stability through combinatorial mutation design, achieving significant affinity gains while maintaining developability.
Susanne H. D. Ständer, Cyril F. Reboul, Sarah N. Le…·Ashley M. Buckle
This study characterizes the structure and dynamics of GAD65 and its interaction with autoantibody b96.11, revealing how intrinsic conformational flexibility drives autoantigenicity.
Emanuela Ruggiero, Maja Marušič, Irene Zanin…·Sara N. Richter
The paper investigates the selectivity of the iMab antibody for i-motif structures, showing it binds both intramolecular and intermolecular iMs, and highlights the impact of experimental conditions on binding.
Cristian David Peña Martinez, Mahdi Zeraati, Romain Rouet…·Daniel Christ
The paper identifies over 650,000 i-motif structures in human genomic DNA using immunoprecipitation and sequencing, showing their widespread distribution and association with highly expressed genes and G0/G1 phase upregulated genes.
Nicky Jonkhout, Sonia Cruciani, Helaine Graziele Santos Vieira…·Eva Maria Novoa
The paper investigates the subcellular relocalization of TRMT1 and TRMT1L during neuronal activation and identifies their role in RNA modification dynamics and neuronal plasticity.
Nathan W. Zammit, Owen M. Siggs, Paul Gray…·Shane T. Grey
The paper identifies TNFAIP3 variants in humans, Denisovans, and mice that modulate A20 phosphorylation, revealing a genetic mechanism for balancing immunity and microbial tolerance.