Karl Forchhammer

This paper engineers the PirC-PGAM switch in cyanobacteria to redirect carbon flux toward desired products like sucrose and succinate, demonstrating a tunable control point for metabolic engineering.

This paper shows that integrating a genetically engineered cyanobacterium into a natural microbial community improves its resilience and PHB production, making it suitable for industrial bioplastic production.

The paper identifies pteridines, including lumazine dehydroxyxanthopterin B2, as natural ligands of CutA that modulate copper binding and redox homeostasis in E. coli and Synechococcus elongatus.

The paper reconstitutes glycogen synthesis in vitro using Synechocystis enzymes to show how different synthases produce distinct glycogen structures and functions.

The paper investigates the role of c-di-AMP and SbtB in cyanobacterial diurnal metabolism, finding that their disruption leads to metabolic dysregulation and diurnal lethality.

This paper identifies structural elements in cyanobacterial iPGAM that mediate regulation by PirC, showing how deletions affect enzyme activity and carbon flux, with implications for biotechnological applications.

This paper develops a genetically engineered filamentous cyanobacterium that continuously produces PHB without nitrogen starvation, maintaining cell viability for sustainable industrial production.

This study identifies FBPase in Synechocystis as a monofunctional enzyme that supports heterotrophic growth without redox regulation, distinct from the bifunctional F/SBPase.

The paper investigates how OpcA regulates G6PDH in cyanobacteria through redox-dependent conformational changes, revealing a novel allosteric mechanism.

ModiFinder localizes structural modification sites in small molecules by aligning MS/MS spectra of known and unknown compounds.

This study identifies SbtB as a redox-regulated apyrase that modulates bicarbonate transporter SbtA activity in cyanobacteria by integrating metabolic and carbon status signals.