Synthetic BiologyActa Pharmaceutica Sinica BPeer-reviewed
Glycodiversification of gentamicins through in vivo glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity
Xinyun Jian, Cheng Wang, Shijuan Wu…·Yuhui Sun
This study creates novel hybrid aminoglycoside antibiotics by swapping glycosyltransferases between gentamicin and kanamycin producers, resulting in compounds with potent activity and reduced ototoxicity.
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