Daniel Lingwood

A hyperglycosylated influenza neuraminidase immunogen reshapes humoral immunity and elicits antibodies targeting a conserved tetramer-interface epitope.

The paper identifies a durable, diverse GC-independent memory B cell population that provides rapid protection from influenza challenges.

This paper uses humanized mice to study how HIV resistance to broadly neutralizing antibodies (bNAbs) affects the efficacy of AAV-delivered immunotherapy, finding that escape mutation fitness costs and resistance benefits determine therapeutic success.

DNA origami particles displaying eOD-GT8 with a synthetic T helper epitope gave antigen-focused germinal centers and expanded VRC01-class precursors in humanized mice after one immunization.

This paper introduces a modular immunogen platform that displays multiple hemagglutinin subtypes and elicits cross-reactive immune responses against influenza subtypes not included in the immunogen.

This study investigates the role of lupus-associated innate receptors in the extrafollicular development of autoreactive B cells using adoptive transfer and time-stamped analysis in a mouse model.

This study evaluates how bNAb epitope specificity, Env sequence, and Fc engineering affect antibody-mediated effector functions against diverse HIV-1 strains.

The paper isolates glycan-reactive antibodies from HIV-1 vaccine trial participants and finds they neutralize diverse HIV strains and show broad cross-reactivity against other pathogens.

The paper uses neuraminidase-on-a-string nanoparticles to show that antigenic distance between strains influences the breadth and cross-reactivity of humoral immunity.

This study designs immunogens by grafting SARS-2 RBM onto heterologous sarbecovirus scaffolds to elicit broad neutralizing antibodies against sarbecoviruses.

This paper introduces ENTER-seq, a method using engineered lentiviral particles to systematically discover receptor-ligand interactions and map TCR specificity in single cells.