Mya L. Vu

This paper introduces a modular immunogen platform that displays multiple hemagglutinin subtypes and elicits cross-reactive immune responses against influenza subtypes not included in the immunogen.

The paper identifies conserved sites on influenza H1 and H3 hemagglutinin recognized by human antibodies and characterizes their neutralization potential and escape pathways.

The paper assesses viral escape from imprinted broad antibody responses using deep mutational scanning of clonal antibody lineages against influenza HA epitopes, showing escape is possible through epistatic networks in drifted strains.

This study designs immunogens by grafting SARS-2 RBM onto heterologous sarbecovirus scaffolds to elicit broad neutralizing antibodies against sarbecoviruses.