Monica R. Mugnier

The paper analyzes antigenic variation in Trypanosoma brucei during chronic bovine infections, revealing enhanced diversity and a reproducible temporal expression hierarchy of VSGs.

The paper demonstrates that DNA damage induces VSG recombination in T. brucei, leading to antigenic variation and immune evasion.

This study shows that maternal Trypanosoma cruzi infection causes significant placental remodeling and systemic changes, regardless of whether the infection is transmitted to the fetus, and identifies potential biomarkers for prenatal monitoring.

vsgseq2 improves the analysis of VSG expression diversity and abundance in Trypanosoma brucei populations using updated bioinformatics tools.

This study uses PhIP-seq to analyze anti-VSG antibody responses in HAT patients, revealing differences between acute and chronic forms and identifying diagnostic targets.

The paper sequenced clinical T. cruzi isolates, finding genomic instability and a unique antigen repertoire absent in lab-adapted strains.

This study identifies immune-related gene expression changes in asymptomatic Chagas cardiomyopathy patients, suggesting unique immune mechanisms in early disease progression.

This study uses high-resolution scRNA-seq to uncover how genomic rearrangements during antigen switching in Trypanosoma brucei depend on repair mechanisms and homologous templates.

This paper develops a reproducible murine model of T. brucei-induced myocarditis and cardiac dysfunction, showing immune-mediated cardiac damage and elevated NT-proBNP levels.

This study shows splenic follicular B cells worsen heart failure after MI by presenting cardiac antigens via MHC II, promoting adverse cardiac remodeling.

The paper identifies B cell gene expression and interactions in healthy and diseased human myocardium, finding disease-specific changes in DCM and ARVC.

The paper presents a high-quality whole genome assembly of a Trypanosoma cruzi hybrid strain using nanopore sequencing, revealing insights into genomic structure and surface protein diversification.