Jeffrey M. Harder

This study identifies immunosuppressive mechanisms in osteosarcoma using single-cell and spatial transcriptomics, revealing interactions between MDSCs, T-cells, and tumor cells that promote an immunosuppressive microenvironment.

This study investigates the role of TLR4 in chronic glaucoma using a mouse model and finds no significant effect on glaucomatous progression.

The paper models metabolic disease susceptibility and resilience in genetically diverse mice by analyzing diet-induced metabolic responses across three strains.

The paper characterizes the CAST/EiJ mouse strain as a model for severe COVID-19 by showing it develops high viral burdens, severe lung pathology, and cytokine dysregulation leading to mortality.

This study identifies early metabolic and inflammatory changes in microglia from a glaucoma mouse model and shows radiation therapy reverses these changes.

The paper shows oral pyruvate protects against glaucomatous neurodegeneration in mice by improving bioenergetics and inhibiting mTOR.