Boris Striepen

The paper identifies an RNA-binding protein essential for female gamete development and sporozoite infectivity in Cryptosporidium by analyzing single-cell data and conducting conditional ablation experiments.

The paper identifies a multi-kingdom microbial consortium that normalizes immune responses in laboratory mice, altering cancer outcomes and CAR T cell therapy responses.

This study identifies a complex male fertilization apparatus in Cryptosporidium, essential for infection, and shows that disrupting HAP2 prevents fertilization and clears infection.

The paper creates a single-cell and spatial transcriptomics atlas of the ileum during diverse infections, revealing novel cell states and immune responses.

This study reveals how Cryptosporidium remodels its single rhoptry into the host interface during invasion and intracellular parasitism.

The paper identifies genomic heterogeneity at the NDH2 locus in Cryptosporidium species that contributes to clofazimine resistance through adaptive recombination.

This study investigates the role of integrins in T cell trafficking and resistance to Cryptosporidium parvum, finding that integrin L is critical for T cell-mediated control of infection while 4β7 is not essential.

The paper identifies genomic loci associated with virulence in Cryptosporidium parvum by analyzing genetic crosses and whole-genome sequencing in mice.

This study uses single-cell RNA sequencing to analyze how intestinal epithelial cells respond to Cryptosporidium infection and IFN-gamma, showing delayed parasite reduction with cytokine treatment.

The paper investigates the role of intestinal cDC1s in CD4+ T cell-mediated resistance to Cryptosporidium, showing they support T cell expansion and effector function through IL-12-dependent and -independent mechanisms.

The paper presents a new high-quality genome assembly and annotation for Cryptosporidium parvum IOWA, revealing structural and functional insights into its genome and evolutionary relationships with related species.

This study identifies 396 novel lncRNAs in Cryptosporidium parvum using RNA-seq, showing differential expression and potential regulatory roles.