Saskia J.E. Suijkerbuijk

NucLogic provides a fast and robust 3D nuclear segmentation method that outperforms existing tools at low SNR and enables quantitative analysis of challenging biological imaging data.

This study uses expansion microscopy to analyze three-dimensional ultrastructure of intestinal tissues and organoids, revealing disease-specific phenotypes in a microvillus inclusion disease model.

This study shows that mechanical signals from the Collagen I-rich matrix drive fate transitions in colorectal cancer cells, enabling metastasis despite lacking Lgr5 expression.

This study shows that cell competition in the liver promotes metastatic intestinal cancer through a multistage process involving compaction, cell cycle arrest, differentiation, and reduced cellular fitness.