Wenxuan Du

This paper introduces a 3D in vitro assay to study immune cell infiltration and cytotoxicity in solid tumors, showing it captures key steps of immune cell interaction with the tumor microenvironment.

This study identifies peripheral genetic drivers of neurodegenerative disease progression using a novel two-stage framework linking genetic variants to longitudinal molecular traits and disease phenotypes.

This study shows human monocytes form patterned multicellular domains on soft matrices through local adhesion and global inhibition, with a computational model validating the mechanism.

This study identifies high-motility tumor-associated monocytes (TAMos) that drive macrophage infiltration and cancer cell proliferation via IL-6 and MAPK pathways, suggesting IL-6 as a therapeutic target.

The paper shows that breast cancer cell-derived small extracellular vesicles (EVs) become more adhesive and metastatic when produced in stiff matrices, promoting cancer spread through enhanced chemotaxis and fibroblast reprogramming.

This paper develops velocity receptors (VRs) to enhance CAR T cell migration through solid tumors, improving tumor infiltration and survival.