Xiong Weng

This study identifies HA and its receptors CD44/RHAMM as key drivers of obesity-related glomerulopathy, showing their role in renal inflammation, fibrosis, and dysfunction, and suggests they as therapeutic targets.

This study evaluates 'kill or cure' strategies for MFN2-related lipodystrophy, finding that ethanol mildly worsens the condition in mice while rapamycin is well-tolerated but lacks efficacy in targeting Mfn2R707W cells.

This study shows that deleting CD44 in preadipocytes promotes adipogenesis by suppressing PPARγ and cell cycle pathways, suggesting CD44 as a therapeutic target for obesity-related metabolic diseases.

This study shows that deleting Alms1 in mesenchymal cells in mice causes metabolic issues similar to Alström Syndrome, including insulin resistance and fatty liver.