Cancer BiologyJournal of Clinical InvestigationPeer-reviewed
PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma
Ryan J. Duchatel, Evangeline R. Jackson, Sarah Parackal…·Matthew D. Dun
This study identifies PI3K/mTOR as a targetable genetic dependency in DIPG and demonstrates that combining paxalisib with metformin improves survival in xenograft models.
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