Andrea Raimondi

This study identifies a reversible temperature block that captures pre-lysosomal intermediates of ERphagy, showing their formation requires autophagy machinery and reveals their structural features.

The paper identifies a RAC1-PLCγ2 axis that decodes EGFR ligand bias by linking receptor trafficking to metabolic programs supporting cell migration.

This study shows EBV uses ER stress and TMX4 to remodel the nuclear envelope, enabling capsid egress during viral maturation.

This study identifies perineurial cells as integrators of leptin and sympathetic outflow, showing their role in obesity protection through barrier function and beta 2 adrenergic receptor regulation.

This study identifies IL-16 production as a mechanism of resistance to BTK inhibitors and R-CHOP in lymphomas, showing that targeting the IL-16/CD9 axis restores drug sensitivity.

This study shows that circulating extracellular vesicles from Parkinson's disease patients induce microglial senescence and neurodegeneration by promoting inflammation and neuronal damage.

This study identifies GL-Lect driven endocytosis as a driver of metastatic plasticity in breast cancer and shows pharmacologic inhibition can suppress invasive phenotypes.

This study shows that human CD4+ memory T cells use ER-phagy and mitophagy to regulate ER and mitochondrial mass during activation and contraction phases.

This study shows tattoo ink causes long-term inflammation in lymph nodes and reduces vaccine efficacy against COVID-19.

This study shows that intrinsically disordered regions (IDRs) of ER-phagy receptors drive ER fragmentation, not their membrane-remodeling domains.

The paper introduces PRINCESS, a novel biosensor that simultaneously detects membrane contact sites and measures associated Ca2+ dynamics using splitFAST technology.

The paper shows that EGFR signaling via non-clathrin endocytosis requires a tripartite organelle platform linking Ca2+ oscillations to mitochondrial metabolism and ATP production for actin remodeling and collective motility.

This paper introduces Membrane-Sensing Peptides (MSP) as universal affinity ligands for analyzing Extracellular Vesicles and analogues, demonstrating their ability to detect EV-associated epitopes in clinical samples without prior isolation.