Håvard T. Lindholm

The paper identifies Prostaglandin E2 as a key mediator of crosstalk between intestinal smooth muscle tissue and epithelium in tumor development, showing reciprocal effects on both cell types.

The paper quantifies viral mimicry in genomes across species and shows how repetitive elements maintain pathogen-like features under selection.

The paper uses single-cell spatial transcriptomics to identify coordinated cellular programs in MSS colorectal cancer that correlate with prognosis.

This study shows that LSD1 in intestinal epithelial cells controls immune cell composition postnatally, independent of microbiota.

This study shows that intestinal-epithelial LSD1 deletion leads to increased pathogenesis in inflammatory and infectious disease models by impairing cytoskeletal organization and goblet cell effector responses.

This study identifies LSD1 as a repressor of a neonatal/reparative gene program in adult intestinal epithelium, showing its role in Paneth cell differentiation and regenerative capacity.