Kevin N. Couper

This study uses reporter mice to visualise NLRP3 inflammasomes in vivo, revealing their localisation, organisation, and cellular sources.

PISTACHIO improves spatial cell-type deconvolution in tumours using proteomics constraints and non-negative matrix factorization.

This study uses vascularised cerebral organoids treated with atorvastatin to model intracerebral haemorrhage and assess tissue injury and immune response.

This study shows that cell volume changes in macrophages enhance type I interferon signaling and inflammation through a DNA- and STING-dependent mechanism.

This study shows that SOX9 is critical for maintaining granuloma structure and ECM barrier formation in schistosomiasis, which protects the liver from damage.

The paper presents a spatially resolved single-cell atlas of lung tissue from fatal Covid19 cases in an African population, revealing a distinct cellular signature and an interferon gamma-dominated response.

This study uses imaging mass cytometry to analyze spatial immunological differences in vestibular schwannomas from NF2 SWN patients, revealing niche-dependent T-cell regulation.