Tyler T. Cooper

This study isolates extracellular vesicles from minimal ascites fluid using strong anion exchange magnetic beads, enhancing proteomic depth and identifying new proteins and SERS signatures in ovarian cancer-derived EVs.

This study shows that SMARCA4 loss in endometrial cancer leads to cell state chaos, not stemness, causing dedifferentiation through epigenomic dysregulation.

The paper shows hypoxia induces TSS switching via H3K4me3 changes, altering translation of key metabolic genes like PDK1.

The paper identifies proteomic differences in urinary extracellular vesicles from pediatric nephrotic syndrome patients during active disease versus remission, linking them to podocyte injury.

This study shows syngeneic adipose-derived stromal cells (ASCs) modulate early macrophage responses but are cleared by 2 weeks in DAT implants, with no long-term regenerative impact.

This study compares Thermolysin and Trypsin/LysC proteolysis for enhancing proteomic analysis of ovarian cancer extracellular vesicles, finding Thermolysin improves peptide complexity and identifies unique proteins like Ly6E and NODAL.

This study shows Nek2 regulates neural differentiation by controlling metabolism, specifically preventing HIF1 stabilization to enable oxidative phosphorylation.

This study shows lactate promotes XEN cell differentiation in mouse embryos by enhancing glycolytic activity and lactate accumulation.