Susan Bonner‐Weir

This study profiles small non-coding RNAs in aging β-cells and islet macrophages, identifying age-related changes in miRNAs and tRFs linked to inflammation and mitochondrial function.

This study shows that inhibiting Renalase protects β cells from stress by shifting metabolism towards glycolysis and GSH synthesis in both mice and humans.

This study shows that knocking out ALDH3B2 in human pancreatic duct cells converts them into beta-like cells that function and reduce blood glucose in mice.

This study shows that sustained high glucose reduces translation of mRNAs involved in insulin secretion in beta-cells, impairing their function.