Adrienne E. Dubin

The paper identifies structural elements in OSCA channels that differentially mediate stretch and poking activation through mutagenesis and electrophysiology.

This study identifies PIEZO2 as a mechanotransducer in juxtaglomerular cells that regulates renin release and blood pressure.

The paper shows that a gain-of-function PIEZO2 mutation in sensory neurons causes joint contractures in mice, and that Botox and dietary fatty acids can alleviate these defects.

The paper uses FM 1-43 dye to identify PIEZO2-expressing neurons involved in mechanosensation, revealing its role in urethral neurons during urination.