Wanting He

The paper designs native-like HIV Env single-chain trimers (SCTs) that are stable, immunogenic, and compatible with vaccine delivery methods.

This study isolates and characterizes V2 apex-directed neutralizing antibodies from SHIV-infected macaques, revealing structural and genetic features that enable broad neutralization.

This study shows that germline-targeting SCIVs can activate and expand B cells expressing V2-apex bnAb-like precursors in rhesus macaques.

The paper analyzes the genetic evolution and mutation patterns of SARS-CoV-2 using phylogenetic and structural analysis of 4,894 genomes, identifying potential human-adaptation related mutations.