Eva Nogales

This study investigates how tau protein regulates motor proteins on microtubules using single-molecule imaging, cryo-EM, and MD simulations, revealing distinct mechanisms for inhibiting kinesin-1 and dynein.

This study presents the structure of the human TIP60-C HAT module bound to a nucleosome, revealing how it positions the catalytic center on the nucleosome surface and engages the linker DNA.

This study shows FoxO1 and HNF1α work together to change nucleosome structure and stability to activate transcription.

This study reports cryo-EM structures of PRC2.1 complexes with different cofactors, revealing how they diversify function while maintaining conserved catalytic mechanisms.

Cryo-EM shows human Ndc80 and Ska complexes bound to adjacent microtubule protofilaments, linked by a SKA3 tether that passes Ska's preference for GTP-like lattice and tip tracking to Ndc80.

This study uses cryo-EM and cryo-ET to reveal how the WD40 domain of KIF21B interacts with microtubules, identifying two binding states and suggesting its role in microtubule regulation.

This paper determines the cryo-EM structure of retron-Kva2 and designs synthetic triggers to activate its antimicrobial activity.

This study identifies MTCL1 as a factor linking microtubule stabilization and acetylation, showing its role in neuronal function through molecular mimicry.

This study identifies MAP9 as a microtubule stabilizer that promotes neuronal morphogenesis and differentially regulates kinesin motor activity.

This study investigates the cytoskeletal organization of astrocytes and shows how microtubule and actin structures contribute to their complex branching morphology.

This study determines the structure of RECQL5-bound Pol II elongation complexes using cryo-EM, revealing how RECQL5 stabilizes Pol II and modulates its translocation state to reduce transcription stress.

The paper reports cryo-EM structures of A-clade R2 retrotransposon proteins during key steps of transgene insertion and identifies features contributing to their selectivity and function.

The paper shows Fe starvation in green algae leads to a second LHCI tetramer associated with PSI, similar to cyanobacteria's isiA antenna ring.

The paper reveals how H3K4me3 and H3K36me3 inhibit PRC2 activity by blocking its interaction with chromatin and allosteric activators, using cryo-EM.

This study engineers a minimal EDV for genome editing by removing viral components, showing improved efficiency and reduced size.

This study investigates how HURP regulates Kif18A motility and microtubule dynamics during mitosis using single-molecule imaging and Cryo-EM.

The paper reveals a mechanism by which automethylated PRC2 dimerizes on chromatin to allosterically activate another PRC2 protomer for H3K27me3 methylation.

The paper reveals the structure of the OCP-PBS complex and elucidates the quantum mechanism of energy transfer during non-photochemical quenching in cyanobacteria.

The study determines the cryo-EM structure of the auto-active NRC4 resistosome, revealing a hexameric configuration that triggers immune responses via cytosolic Ca2+ influx.

The paper reports the cryo-EM structure of the yeast NuA4 complex hub and describes its interaction with HAT and TINTIN modules for nucleosome recognition.

This paper identifies how herpesviral TBP mimics interact with RNA polymerase II to drive late gene transcription, distinguishing viral from cellular TBP function.

This study presents the structure of the yeast RSC chromatin remodeler, revealing its core and flexible lobes and how it interacts with nucleosomes.

The paper uses cryo-EM to determine the atomic structure of tau-tubulin interactions, revealing how tau stabilizes microtubules through specific binding sites.