Cancer BiologyJournal of Clinical InvestigationPeer-reviewed
Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition
Kristen E. Kay, Juyeun Lee, Ellen S. Hong…·Justin Durla Lathia
This study shows that spermidine, a metabolite from glioblastoma cells, suppresses CD8+ T cell function, promoting tumor growth and poor patient outcomes.