Author

José O. Castellón

University of California, Los AngelesORCID 0000-0003-4907-5655Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:deep learning· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Ashley R. JulioiD· 2 shared Keriann M. BackusiD· 2 shared Lisa M. BoatneriD· 2 shared Robert D. DamoiseauxiD· 2 shared Alexandra C. TurmoniD· 1 shared Ann L. Zhou· 1 shared Brandon Han· 1 shared Cameron TayloriD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Ashley R. JulioORCID

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2 papers

Recent·Most cited

BiochemistryRSC Chemical BiologyPeer-reviewedJan 1, 2025

An activation-based high throughput screen identifies caspase-10 inhibitors

José O. Castellón, Constance Yuen, Brandon Han…·Keriann M. Backus

This study identifies caspase-10 inhibitors using an activation-based high-throughput screen, revealing inhibitors that preferentially target the zymogen form of caspase-10.

DOI 10.1039/d5cb00017c

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistryJournal of the American Chemical SocietyPeer-reviewedMay 24, 2024

Chemoproteomics identifies proteoform-selective caspase-2 inhibitors

José O. Castellón, Samuel Ofori, Nikolas R. Burton…·Keriann M. Backus

The paper identifies proteoform-selective caspase-2 inhibitors using chemoproteomics, revealing a unique non-catalytic cysteine and validating their selectivity and activity.

22 citations

humanproteomics

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