Lisa M. Boatner

This paper introduces GRIPs, a scalable platform for PTM editing using chimeric molecules, demonstrating functionality in multiple systems and confirming specificity through proteomics.

This study identifies caspase-10 inhibitors using an activation-based high-throughput screen, revealing inhibitors that preferentially target the zymogen form of caspase-10.

The paper identifies proteoform-selective caspase-2 inhibitors using chemoproteomics, revealing a unique non-catalytic cysteine and validating their selectivity and activity.

The paper introduces a two-stage enrichment method called Cys-Surf to profile the cell surface cysteinome, identifying 821 ligandable cysteines and redox-sensitive residues with functional implications.