Zelin Shan

This study uses cryo-EM to show how filamentation in bovine GDH alters its allosteric response to GTP inhibition, revealing structural mechanisms with implications for disease treatment.

This paper identifies a low-affinity SARS-CoV-2 antibody, P5-1C8, that neutralizes Omicron JN.1 through IgG-mediated spike aggregation rather than direct binding.

This study determines cryo-EM structures of HIV-1 integrase tetramers and intasome hexadecamers, revealing structural plasticity and functional roles in viral integration and RNA binding.

This study identifies how RORγt mutations affect gene activation by altering chromatin binding modes, explaining context-dependent autoimmunity and host defense outcomes.

The paper presents two cryo-EM structures of filamentous SgrAI to elucidate the two-metal ion mechanism of DNA cleavage during enzymatic activity.