Tung Dinh

The paper shows that HIV-1 integrase C-terminal domain mutations affect sensitivity to ALLINIs by altering gRNA binding, despite being distant from the drug binding site.

This study determines cryo-EM structures of HIV-1 integrase tetramers and intasome hexadecamers, revealing structural plasticity and functional roles in viral integration and RNA binding.

This paper identifies the mechanism of resistance to the HIV-1 integrase inhibitor pirmitegravir and develops a more potent analog to overcome this resistance.