Darren S. Dumlao

The paper identifies an adipose-complement-lipid axis that systemically regulates sensory neuron sensitization, explaining pain-structure discordance in obesity-associated osteoarthritis.

This study shows that absence of complement factor D increases pressure-pain hyperalgesia in mice after medial meniscus injury despite cartilage protection.

This study shows that the gut microbiome affects methotrexate pharmacology in mice and contributes to interindividual variation in drug metabolism and treatment outcomes.

This study shows that a ketogenic diet reduces autoimmune disease in mice by altering host metabolism and shaping gut microbiota, specifically through β-hydroxybutyrate and Lactobacillus species.

The paper shows that a bacterial operon in the gut microbiome can reduce drug toxicity during cancer treatment by inactivating 5-fluorouracil.