Hanna-Kaisa Vikkula

This study reinstates RIG-I and RNF135 in chickens to investigate their role in avian influenza response, finding that their expression exacerbates inflammation and mortality without affecting viral replication.

This study creates IFN receptor knockout chickens to investigate IFN dynamics in influenza infection, revealing strain-specific roles and highlighting type I IFN's importance in initial defense against H3N1.