Author

Patrick S. Costello

The Francis Crick InstituteORCID 0009-0000-4419-5012Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Diane MauriceiD· 2 shared Richard TreismaniD· 2 shared Bruno FredericoiD· 1 shared Francesco GualdriniiD· 1 shared Jessica DiringiD· 1 shared María Benito-JardóniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 12 mutual co-author links

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2 shared papersImmunology

Diane MauriceORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintOct 8, 2026

The MRTFs are required for thymocyte trafficking and Treg-mediated immune tolerance

Patrick S. Costello, Diane Maurice, María Benito-Jardón, Richard Treisman

This study shows that MRTF-SRF signaling is critical for thymocyte egress and Treg-mediated immune tolerance, leading to autoimmune phenotypes in MrtfabKOT mice.

DOI 10.64898/2026.10.02.756229

mouseexperimental assay

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ImmunologyNature CommunicationsPeer-reviewedSep 11, 2024

Defective cytoskeletal dynamics underlies the essential role of MRTF-SRF in IL-2 delivery to CD8+ T cells during infectious challenge

Diane Maurice, Patrick S. Costello, Jessica Diring…·Richard Treisman

This study shows that MRTF-SRF is essential for CD8+ T cell expansion and memory persistence during infection by regulating cytoskeletal dynamics and IL-2 signaling.

5 citations

mousebulk RNA-seq

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