Niek Wit

This study identifies ZFAND5/6 as ubiquitin-independent proteasome activators that regulate NF-κB signaling by degrading UBCH5c.

The paper identifies CBF-beta as a negative regulator of STING through synthetic lethality screens in VHL-null ccRCC cells, showing its role in type I interferon signaling and tumor growth.

The paper identifies SETD2 as a regulator of iron metabolism by modulating ferritin breakdown, affecting cellular iron levels and ferroptosis resistance.

This study identifies ABHD11 as a deglutarylating enzyme that regulates T cell metabolism by maintaining TCA cycle integrity through removal of glutaryl-lipoyl adducts.

This study identifies Periphilin as the RNA-binding component of the HUSH complex and shows that RNA-binding is essential for HUSH function.

The paper identifies USP43 as a deubiquitinating enzyme that enhances HIF-1 nuclear accumulation and target gene binding through interaction with 14-3-3 proteins under hypoxia.

This study shows hypoxia induces HIF2-dependent cell cycle entry in macrophages, leading to increased susceptibility to lentiviral transduction and is observed in tumor-associated macrophages.