Author
Harvard UniversityORCID 0009-0003-1740-161XUnclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Yingxiao Shi, Priyanka Sharma, Jia‐Ren Lin…·Genevieve Marie Boland
This study identifies genomic subtypes and immune features of mucosal melanoma, linking CD163+ macrophages to immune resistance and suggesting TIM-3 blockade as a therapeutic target.
Joseph Amick, Shamika Bhandarkar, Douglas R. Wilcox…·Chenghua Gu
STED imaging quantifies luminal versus abluminal localization of blood-brain barrier proteins in vivo; tyrosine motifs drive abluminal sorting of OAT3 and MHC I, and CD31 shifts day to night.
Alex Y. H. Wong, Yi Daniel Lu, Ziyuan Zhao…·Peter Karl Sorger
The paper introduces v-CyCIF, a method for 3D spatial profiling of human FFPE tissue, enabling detailed analysis of tumor, stroma, and immune structures.
Tanzina Tanu, Anna M. Cox, Jennifer A. Karlow…·Megan L. Insco
This study identifies ZC3H18 mutations that stabilize endogenous retroviral RNA, linking ERV RNA accumulation to oncogenesis in zebrafish and human cell lines.
Emmanuel C. Ogbonna, Soheil Rastgou Talemi, Zoltan Maliga…·Peter Karl Sorger
This study uses 3D reconstruction and optimal transport modeling to analyze TLS development in TB-infected lungs, revealing distinct maturation trajectories and spatial dynamics.
Clarence Yapp, Ajit J. Nirmal, Felix Zhou…·Peter Karl Sorger
This paper introduces 3D CyCIF, a method for high-plex 3D profiling of cell states and immune niches in human tumors, revealing detailed spatial interactions and cytokine niches previously unattainable in thin sections.