Takuro Horii

This study shows that dietary phosphorus restriction allows for the multigenerational breeding of α-Klotho-deficient rats, improving survival and reproductive outcomes.

This study identifies LRBA as a scaffold promoting MAPK activation, leading to drug-induced liver injury and MASLD by enhancing inflammatory signaling.

The paper shows that glucagon dysfunction in the liver leads to PP cell hyperplasia and the emergence of GCG+ PP+ double-positive cells through hyperaminoacidemia and mTOR signaling.

This study shows that changes in branched-chain amino acid (BCAA) metabolism, specifically reduced BCAT2 activity, drive cellular senescence in cultured cells and mice, and link aging to altered BCAA metabolism in humans.

This study identifies RSS as a recyclinopathy caused by dysfunction in the Commander endosomal recycling pathway, linking it to multiple tissue malformations.

This study shows ZIP13 regulates lipid metabolism by modulating intracellular iron and zinc balance in adipocytes.

This study shows that Nwd1 knockout mice develop NASH-like liver pathology due to SERCA2 dysfunction and ER stress.

This study identifies the Keap1-Nrf2 pathway as a regulator of TGF-β-mediated CTGF expression in fibroblasts, showing that Nrf2 with Ddx54 suppresses profibrotic genes and reduces fibrosis in mouse heart and kidney.