Osnat Bartok

The paper identifies Mif as a regulator of tumor immune evasion in low intra-tumor heterogeneity melanoma by analyzing single-cell RNA sequencing data and validating in patient data.

The paper identifies posttranscriptional mechanisms, specifically involving CPSF6 and EIF2S1, that underlie circadian temperature compensation in U-2 OS cells.

This paper describes a method to specifically knock down circRNAs in vivo and shows that circRNA downregulation affects fly development and transcriptome.

PhISCS-BnB computes the most likely perfect tumor phylogeny from single-cell sequencing data, offering optimality guarantees and significant speed improvements over existing methods.

This study shows that temperature changes alter the splicing of the timeless gene in Drosophila, affecting TIM protein levels and activity through temperature-sensitive splicing isoforms.

This paper develops a shRNA-based strategy to knock down circMbl in Drosophila, revealing its functional roles in development, behavior, and synaptic function.