Author

Duohao Ren

Centre National de la Recherche ScientifiqueORCID 0009-0005-4409-8833Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:non-human primate· 1

Frequent Co-Authors

Deniz DalkaraiD· 3 shared Juliette PulmaniD· 3 shared Sylvain FissoniD· 3 shared Anne De CianiD· 2 shared Divya AiliD· 2 shared Hugo MalkiiD· 2 shared Jean‐Paul ConcordetiD· 2 shared Anne H. M. GalyiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersBioengineering

Deniz DalkaraORCID

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3 papers

Recent·Most cited

BioengineeringbioRxivPreprintDec 14, 2025

AAV-delivered CRISPR-Cas9 elicits persistent retinal immune responses compared with transient responses to RNP

Juliette Pulman, Duohao Ren, Laura Visticot…·Sylvain Fisson

This study compares immune responses to AAV-delivered CRISPR-Cas9 and RNP-delivered CRISPR-Cas9 in the retina, finding persistent inflammation with AAV and transient inflammation with RNP.

1 citation

mouseexperimental assay

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ImmunologybioRxivPreprintJun 2, 2025

Inter-individual variability in immune responses to AAV-mediated ocular gene delivery across species impedes reliable immunomonitoring profile

Duohao Ren, Gaëlle Anne Chauveau, Julie Vendomèle…·Sylvain Fisson

The paper shows that immune responses to AAV-mediated ocular gene delivery vary across species and individuals, complicating reliable immunomonitoring.

1 citation

humanmouse

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BioengineeringMolecular Therapy — Nucleic AcidsPeer-reviewedSep 30, 2024

Direct delivery of Cas9 or base editor protein and guide RNA complex enables genome editing in the retina

Juliette Pulman, Catherine Botto, Hugo Malki…·Deniz Dalkara

This study delivers Cas9 or base editor RNP complexes directly to retinal cells, achieving gene editing in photoreceptors and RPE, but with toxicity at high concentrations.

12 citations

mouseCRISPR screen

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